Magnesium

Introduction

The human body contains around 25g of magnesium, whereof approximately 50 to 60% are in bones1. Magnesium is required in more than 300 enzyme processes1. A deficiency leads to a weakening of the body and diseases. An excess intake is not a problem.

Not Enough

Magnesium is important in many functions in the human body. The first recognizable symptom of a deficiency is often over-excitability of muscles and especially cramps.1.

Other symptoms are: loss of appetite, nausea, vomiting, fatigue and weakness2. As the deficiency progresses possible are: numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal hears rhythms, as well as coronary spasms2.

Longer term too low magnesium intake seems to be related to: heart attack, high blood pressure, bone fragility (osteoporosis), diabetes mellitus1.

As a consequence of magnesium deficiency often also calcium deficiency develops. The blood serum concentration of calcium can drop significantly even before any symptoms of magnesium deficiency become identifiable1.

Too Much

It is not possible to eat too much magnesium with normal food1. The body excretes too much magnesium with urine1. As long as there are no intestine or kidney diseases, magnesium from food is absolutely harmless1.

The consequence of an overdose of supplements is usually diarrhea with sometimes nausea and stomach cramps1.

Life threatening much magnesium in the body usually only occurs with infusions or kidney problems1. It may be possible with oral supplements, but large quantities would have to be eaten and it almost never occurs.

Recommended Daily Intake (Total)

The recommended daily allowance from all sources (normal food, supplements etc. together) is according to the Institute of Medicine (US) as follows:

Male 19-30 years400mg per day1
Female 19-30 years310mg per day
Male 31 and older420mg per day1
Female 31 and older320mg per day
Pregnantfrom 360mg to 400mg per day
Lactatingfrom 320mg to 360mg per day

The detailed tables by age and gender can be found here.

Assessment of Status

There are tests to inspect a possible magnesium deficiency.

Magnesium Blood Serum Test
It is the most common test. A result below 0.75 mmol/liter (1.8 mg/dl) shows a magnesium deficiency1. When having insufficient magnesium intake, the body can use up magnesium stored in bones, muscles and internal organs and stabilize the magnesium blood level in a normal range, although a deficiency exists3. That means it is possibly to have magnesium deficiency and still have blood serum levels in the normal range.

Other Tests
There is a multitude of other tests, which can theoretically be administered. Magnesium is stored to 90% in the muscles and bones1 and only 0.3% circulates in the blood serum4. Different kinds of cells in the body can be tested directly for their magnesium content, e.g. mouth mucosa, lymphocytes, muscle cells, red blood cells etc. Another test consists of consuming magnesium and then measuring in the following 24 hours how much is being excreted again with urine5. The less magnesium the body excretes again, the higher is his need for magnesium and therefore the stronger the deficiency.


There are different tests available. A single, simple, cheap, available and accurate test for the personal magnesium status does not exist, yet. Each test has his weaknesses in one or another aspect. The most common blood serum test is inaccurate.

Natural Sources

In the table below some examples of the magnesium content of food is listed.

Magnesium content
Foodper 100g
Spinach cooked687mg
Avocado729mg
Banana827mg
Broccoli921mg
Cauliflower109mg
Lettuce, green 1113mg
Apple 125mg
Bread (Wheat)1341mg
Dark chocolate, 60-69% cacao14176mg
Ground beef1522mg
Salmon1618mg
Trout1731mg
Milk18 (ca. 1 dl)10mg
Cheese, Gruyere 1936mg
Cheese, Brie 2020mg

In a normal diet around 50% of the magnesium in the food is absorbed1.

Phytic acid occurs in many food types, like for example the outer shell of many grains (whole grains)21. Phytic acid reduces the magnesium absorption21. For grains sprouting before processing helps to reduce the amount of phytic acid22. Spinach contains much oxalic acid23. Oxalic acid also interferes with usage of magnesium by the body23,21.

Types of Supplements

There are different magnesium compounds sold as supplements.

  • Magnesium citrate
  • Magnesium oxide
  • Magnesium chloride
  • Magnesium lactate
  • Magnesium aspartate
  • ... others
Which form is best used by the body (highest bioavailability) is not yet conclusively studied21. There are inaccurate studies with humans and studies with rats. Magnesium citrate seems to be better absorbed than magnesium oxide 21.

Maximal Dosage

For magnesium in normal food there are no adverse effects known1.

The Institute of Medicine (US) has published a maximal dosage for supplements. It is based on the intake from where upward diarrhea starts to occur.

The value is 350mg (8 years and older) 1.

More detailed tables by age and gender are available here.

Buy

Magnesium supplements are available in every grocery or drug store.

Conclusion

A light magnesium deficiency is often not recognized, because the symptoms are only weak and many other deficiencies or diseases have similar symptoms (e.g. fatigue). The first recognizable symptom are usually cramps.

A deficiency can be cured with supplements.

An overdose is not a health risk as long as there are no kidney diseases.


References

1
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (1997). Cover of Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK109825/ at 2018-10-21.

2
U.S. Department of Health and Human Services. National Institutes of Health. Office fo Dietary Supplements. (2018). Magnesium - Fact Sheet for Health Professionals. Retrieved from https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ at 2018-10-28.

3
James J DiNicolantonio, James H O’Keefe, and William Wilson. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart, 5(1). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786912/ at 2018-10-27.

4
Uwe Gröber, Joachim Schmidt, and Klaus Kisters. (2015). Magnesium in Prevention and Therapy. Nutrients, 7(9), 8199-8226. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586582/ at 2018-10-27.

5
Swaminathan, R. (2003). Magnesium Metabolism and its Disorders. The Clinical Biochemist. Reviews, 24(2), 47-66. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/ at 2018-10-27.

6
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 11458, Spinach, cooked, boiled, drained, without salt. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/11458 at 2018-10-28.

7
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 09038, Avocados, raw, California. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/09038 at 2018-10-28.

8
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 09040, Bananas, raw. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/09040 at 2018-10-28.

9
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 11091, Broccoli, cooked, boiled, drained, without salt. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/11091 at 2018-10-28.

10
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 11136, Cauliflower, cooked, boiled, drained, without salt. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/11136 at 2018-10-28.

11
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 11253, Lettuce, green leaf, raw. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/11253 at 2018-10-28.

12
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 09003, Apples, raw, with skin (Includes foods for USDA's Food Distribution Program). (National Nutrient Database for Standard Reference Legacy Release ). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/09003?fgcd=&manu=&format=&count=&max=25&offset=&sort=default&order=asc&qlookup=Apples%2C+raw%2C+with+skin&ds=SR&qt=&qp=&qa=&qn=&q=&ing= at 2018-08-26.

13
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 18064, Bread, wheat. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/18064 at 2018-10-28.

14
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 19903, Chocolate, dark, 60-69% cacao solids. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/19903 at 2018-10-28.

15
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 23563, Beef, ground, 90% lean meat / 10% fat, patty, cooked, broiled. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/23563?fgcd=&manu=&format=&count=&max=25&offset=&sort=default&order=asc&qlookup=ground+beef+90%25&ds=SR&qt=&qp=&qa=&qn=&q=&ing= at 2018-08-26.

16
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 15077, Fish, salmon, chinook, smoked. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/15077 at 2018-10-28.

17
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 15115, Fish, trout, rainbow, wild, raw. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/15115 at 2018-10-28.

18
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 01211, Milk, whole, 3.25% milkfat, without added vitamin A and vitamin D. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/01211 at 2018-10-28.

19
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 01023, Cheese, gruyere . Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/01023 at 2018-09-04.

20
United States Department of Agriculture. Agricultural Research Service. (2018). Basic Report: 01006, Cheese, brie. (National Nutrient Database for Standard Reference Legacy Release). Retrieved from https://ndb.nal.usda.gov/ndb/foods/show/01006 at 2018-09-04.

21
Jan Philipp Schuchardt and Andreas Hahn. (2017). Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update. Current Nutrition and Food Science, 13(4), 260-278. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652077/ at 2018-10-28.

22
Raj Kishor Gupta, Shivraj Singh Gangoliya, and Nand Kumar Singh. (2013). Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains. Journal of Food Science and Technology, 52(2), 676-684. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325021/ at 2018-10-28.

23
Bohn T, Davidsson L, Walczyk T, Hurrell RF. (2004). Fractional magnesium absorption is significantly lower in human subjects from a meal served with an oxalate-rich vegetable, spinach, as compared with a meal served with kale, a vegetable with a low oxalate content. The British Journal of Nutrition, 91(4), 601-606. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15035687 at 2018-10-28.